Developing open-access model production facility blueprints
Open-access blueprints would provide a head start on facility design and allow equipment manufacturers and engineering companies to address standard industry needs.
Cultivated
Systematic investigation of growth factor needs and effects
Open-access research into growth factors required for proliferation, maintenance, and differentiation of cell types relevant to cultivated meat will support both academic and industry research efforts. This research could include screening of species-specific growth factors under a variety of conditions and in a variety of cell types to characterize cross-species compatibility, which informs commercial efforts to scale production of the most widely used growth factors. Research should also seek to define optimal concentrations of individual growth factors and cocktails for achieving various cell states or behaviors, as well as understanding interactions between growth factors.
Development and industry-wide adoption of standards for meat characterization
A more comprehensive understanding of the processes, structures, and molecular constituents governing meat's organoleptic properties will inform the production of alternative proteins.
Computational models of perfusion flow through scaffolds
For tissue-structured cultivated meat production, the transition from the proliferation phase to differentiation phase may involve seeding cells onto a prefabricated scaffold within a perfusion bioreactor. Medium is then perfused through the cell-laden scaffold, providing nutrients and oxygen as cells differentiate and mature. Computational models are needed to describe fluid flow through scaffolds to better understand mass transfer and shear forces. These models will inform considerations for scaffold materials, geometries, dimensions, fabrication methods, and bioprocess design as well as considerations for the composition and viscosity of the medium.
Expand capacity for demonstration-scale and mid-scale co-manufacturing
Companies entering the alt protein space often struggle to secure line time at demonstration-scale and mid-scale commercial production facilities. Greater availability of mid-scale contract capacity would reduce capital outlays and facilitate scaling, allowing alt protein companies to maintain greater control over their equity and exercise more influence within the supply chain. Contracting production allows for a more modular supply chain, with participants achieving gains from specialization, allowing for better financial and organizational structuring around core competencies.
Establishing intellectual property pooling frameworks
Intellectual property pools and patent pledges can help member companies contribute to a suite of patents that can be licensed within the pool.
Platform for facilitating matchmaking between funders and funding-seekers
It can be challenging and time-intensive for startups and researchers to find funders that are interested in their technology area, technological maturity level, fundraising stage, location, type of funding sought, and other factors. Lists of investors, lenders, and grant-making institutions with specific information on interest areas and point of contact can significantly reduce friction in fundraising. Likewise, it can be difficult for funders to find out about these opportunities, so centralized listings of all companies and researchers actively seeking funding can facilitate deal flow.
Infrastructure loan fund
The success of early-days products has demonstrated strong consumer interest, but investment is needed to enable alternative protein supply chain companies to build out the infrastructure needed to capitalize on this opportunity. In particular, there is a need for debt-based financing that can be structured to support large infrastructure projects.
Infrastructure and equipment leasing fund
Infrastructure leasing for production and processing facilities as well as capital equipment would enable alternative protein companies to rapidly expand capacity without large upfront capital investments. Having leasing funds and leasing companies with an alternative protein focus could entice corporate players who otherwise would not have considered alternative proteins to enter the space. They could also spare many smaller alternative protein startups from undertaking relatively expensive, equity-backed capital raises early in their expansion.
Industry workshops, courses, and training programs
The alternative protein industry has a significant need for workers and innovators with specialized knowledge spanning multiple traditional disciplines. However, since few universities offer alternative protein majors or dedicated subject matter, most alternative protein knowledge has to be learned on the job. The alternative protein industry needs educational programming that can cover the depth and complexity of knowledge, experience, and skills required within the context of traditional academic institutions as well as post-graduate professional development and training opportunities.
