40Research opportunities
44Commercial whitespaces
39Ecosystem support needs
Key: Cultivated icon Cultivated Fermentation icon Fermentation Plant-based icon Plant-Based
Opportunity Production platform Solution category Value chain segment Technology sector Maturity level
Novel methods for long-chain omega-3 fatty acid production

As the alternative seafood industry scales up, a low-cost and abundant source of long-chain omega-3 polyunsaturated fatty acids will become necessary. Several means of producing these compounds have been investigated…

Fermentation icon Fermentation Research R&D Raw Materials, Ingredients, & Inputs Bioprocess design Host strain development Ingredient optimization Target molecule selection
Preventing oxidation of omega-3 fatty acids before and after addition to alternative seafood products

Deeper fundamental knowledge of the causes and prevention of oxidation of omega-3 fatty acids before, during, and after addition to alternative seafood products is needed to improve their nutritional and…

Cultivated icon Cultivated Fermentation icon Fermentation Plant-based icon Plant-Based Research End Products Investment Production R&D Raw Materials, Ingredients, & Inputs Bioprocess design Crop development End product formulation & manufacturing Host strain development Ingredient optimization Target molecule selection
Understanding uptake and interconversion of omega-3 fatty acids by cultivated fish cells

Although fish are one of the best dietary sources of long-chain omega-3 fatty acids (FAs), these compounds are mostly bioaccumulated from a fish’s diet rather than synthesized de novo. Consistent…

Cultivated icon Cultivated Commercial Research R&D Raw Materials, Ingredients, & Inputs Cell culture media Cell line development Host strain development
Scaffolding development for culinary and biomechanical requirements of cultivated seafood

A number of published studies have focused on scaffolds for cultivated meat (see Related Efforts) yet, to our knowledge, no studies have specifically attempted to formulate scaffolds for fish or…

Cultivated icon Cultivated Commercial Research R&D Raw Materials, Ingredients, & Inputs Cell line development Scaffolding 0 – Complete whitespace
Production process innovations for fiber formation and improved plant protein texturization

Fibers from techniques like electrospinning, jet spinning, or blow spinning may be able to impart a desirable texture to a given product.

Plant-based icon Plant-Based Commercial Research End Products Production R&D End product formulation & manufacturing 2 – Early adoption
Improving efficiency and assessment of adaptation to suspension growth

Improving methods for adapting cells to suspension culture can facilitate cell line development and bioprocess design for cultivated meat.

Cultivated icon Cultivated Research R&D Bioprocess design Cell line development 1 – Inception
Species-specific genomic studies enabling assay development for regulatory standards and cell line optimization

A suite of assays and genomic knowledge exists for humans and commonly used laboratory species such as mice or fruit flies. However, the same species-specific infrastructure does not exist equally…

Cultivated icon Cultivated Research R&D Cell line development
Guidelines for cultivated meat starter cell selection

Improving our understanding of the relative advantages and disadvantages of different cell types for cultivated meat would enable companies to make these decisions more effectively with less duplicative effort.

Cultivated icon Cultivated Research R&D Raw Materials, Ingredients, & Inputs Cell line development 1 – Inception
Mapping the secretome of animal myoblasts, adipocytes, and other cells used in cultivated meat

Stem cells secrete a variety of signaling factors that can influence the behavior of surrounding cells, known as paracrine signals. In high-density bioprocesses, these secreted factors can accumulate to concentrations…

Cultivated icon Cultivated Research Production R&D Cell line development
Microbial strain-development contract research organizations for alternative protein applications

While emerging fermentation-derived ingredient companies often optimize their strain’s productivity in-house, it may be more efficacious for startups to engage contract research organizations with both deep microbial strain development expertise…

Fermentation icon Fermentation Commercial Ecosystem Research R&D Host strain development

Get involved

If you’d like to fund a research project, work on any of these solutions, share information about related efforts that are already underway, or elevate new ideas for advancing the alternative protein industry, we’d love to hear from you!

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Explore key innovation priorities

Review commercial whitespaces, research gaps, technological needs, and investment priorities at each stage of the alternative protein value chain.

How we built this

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Executive summary

Get an overview of GFI’s Solutions initiative and a summary of key resources.

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Full report

Delve into the full report on the motivation, methodology, rationale, and key findings and recommendations of the Solutions initiative.

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Futures wheels analysis

Explore our framework for uncovering second-order or third-order consequences and implications of hypothetical future scenarios to support better decision-making in the present.

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Future-proofing

Discover key findings from GFI’s premortem analysis of potential threats to the widespread adoption of alternative proteins, including strategies to avoid or mitigate the most pressing risks.