Improving efficiency and assessment of adaptation to suspension growth
Improving methods for adapting cells to suspension culture can facilitate cell line development and bioprocess design for cultivated meat.
Cultivated
Establishing student groups at key universities
Universities are epicenters for creative problem-solving and cutting-edge research advancements, and they can serve as engines for interdisciplinary innovation. However, this potential is not being tapped fully by the alternative protein industry. University student groups at key universities can foster robust, in-person communities for students and researchers interested in elevating the profile of alternative proteins within the academy. This will generate a talent pipeline of informed and empowered young people poised to enter the sector after their education while simultaneously spurring greater awareness and involvement among established faculty members.
Species-specific genomic studies enabling assay development for regulatory standards and cell line optimization
A suite of assays and genomic knowledge exists for humans and commonly used laboratory species such as mice or fruit flies. However, the same species-specific infrastructure does not exist equally across the species used in cultivated meat, with an especially large gap in seafood species. Commercialized, standardized assays for species identification such as Short Tandem Repeat (STR) or Cytochrome C Oxidase I (COI) assays are needed. Additionally, richer genetic datasets, including thorough genome annotations that facilitate identification of safe harbor loci, can broadly accelerate cell line optimization studies.
Guidelines for cultivated meat starter cell selection
Improving our understanding of the relative advantages and disadvantages of different cell types for cultivated meat would enable companies to make these decisions more effectively with less duplicative effort.
Mapping the secretome of animal myoblasts, adipocytes, and other cells used in cultivated meat
Stem cells secrete a variety of signaling factors that can influence the behavior of surrounding cells, known as paracrine signals. In high-density bioprocesses, these secreted factors can accumulate to concentrations that can dramatically influence productivity and behavior of neighboring cells. By mapping the secretome of animal myoblasts, adipocytes, and other stem cells used for cultivated meat, a better understanding of which factors influence proliferation, differentiation, and other cellular traits can be obtained. Mapping efforts will inform how to best leverage this knowledge to improve cultivated meat production.
“Rainbow roll 2.0” showcase for cultivated seafood
Given the nascent market for cultivated meats, especially for cultivated seafood, a “Rainbow Roll 2.0” product could be an attractive market-entry commercial product.
Guaranteed offtake contracts for products and ingredients
Guaranteed offtake agreements, where buyers commit to purchase a volume of product, can help secure loans for infrastructure and other high-cost projects.
Forging product development partnerships among ingredient suppliers and manufacturers
Opportunities exist to coordinate product development partnerships between ingredient suppliers, strategic partners, and product manufacturers to directly engage more holistically on product formulation.
Species-specific research toolkits for cultivated meat-relevant species
Coordinated efforts to develop standardized, comprehensive research toolkits of meat-relevant species would exponentially accelerate cultivated meat research.
Developing open-access model production facility blueprints
Open-access blueprints would provide a head start on facility design and allow equipment manufacturers and engineering companies to address standard industry needs.
