Reducing cell culture media cost

2022-2024

Dr. Burridge is exploring a process to optimize chemically-defined media protocols around the generation, long-term culture, and scalable differentiation of non-genetically modified porcine and bovine induced pluripotent stem cells (iPSCs).

PRODUCTION PLATFORM: Cultivated

TECHNOLOGY SECTOR:  Cell culture media

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Project aims

This project will work to develop low-cost induced pluripotent stem cell (iPSC) culture and differentiation media. The outcomes will help optimize protocols for bovine and porcine iPSC proliferation and differentiation. This work will also develop skeletal muscle maturation protocols to improve the organoleptic properties of these cells and adapt the differentiation protocol to larger bioreactors. As a result, it will improve the quality and reduce the costs of iPSC culture and differentiation media.

Principal researcher

Dr. Paul burridge, assistant professor, northwestern university, usa

Dr. Paul Burridge

Assistant professor, Northwestern University, USA

Dr. Burridge has experience developing differentiation protocols for biomedical research. His expertise is in using induced pluripotent stem cells (iPSCs) in pharmacogenomics (precision medicine), cardio-oncology, cardiovascular disease modeling, cultivated meat, regenerative medicine, and cancer.

Rendering of cell molecules

Commercialization of Dr. Burridge’s stem cell culture media

Dr. Burridge and an industry startup, Defined Bioscience, are actively working to commercialize a fully-defined, optimized culture medium for human stem cells. Given this, we are confident in Dr. Burridge and his Northwestern University lab’s ability to do the same for utilizing animal stem cells for cultivated meat.

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Optimizing media for chicken cells

Learn about Dr. David Block’s work to perfect growth media for cultivated chicken at University of California, Davis.

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Formulating media with macromolecular crowding

Learn about Dr. Connon and Dr. Gouveia’s work at Newcastle University, UK to formulate growth media for cultivated meat with macromolecular crowding.

Fish

Low-cost differentiation medium for seafood culture

Learn about Dr. Rees’s research to develop low-cost differentiation media for cultivated seafood at Defined Bioscience.

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Analyzing cell culture medium costs

This white paper explains different routes to lowering the cost of cell culture medium and making cultivated meat economically viable.

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Translating biomedical advances to cultivated meat (Biochemical Engineering Journal)

This peer-reviewed article discusses how advances from the biomedical cell culture industry can contribute to the development of cultivated meat.

A battered and fried cultured meat, a cultured chicken cutlet, plated with sauteed greens and mashed root vegetables | image courtesy of upside foods

The science of cultivated meat

Learn about the science of cultivated meat and the challenges that must be addressed for commercial production.