Low-cost differentiation medium for seafood
Dr. Rees, Dr. Ovissipour, and Dr. Duscher are working to develop robust, low-cost differentiation media for seafood culture.
PRODUCTION PLATFORM: Cultivated
TECHNOLOGY SECTOR: Cell culture media
This project will help develop myogenic and adipogenic differentiation media for zebrafish (Danio rerio) embryonic stem cells (ESCs) and adapt this media for sea bass culture. This would reduce costs and optimize media formulations for cultivated seafood production. Beyond zebrafish and sea bass, this work will provide a strong foundation for the development of successful cultivation of other fish species and fish-like cell lines.
Dr. Steven Rees
CEO, Defined Bioscience, Inc., USA
Dr. Rees has a background in biomedical sciences with training in molecular biophysics, pharmacology, and multiscale biology. He is currently focused on creating high-quality reagents, media, and protocols that will reduce the cost of growing stem cells from humans and animals.
Dr. Reza Ovissipour
Assistant professor, Virginia Tech University, USA
Dr. Ovissipour has expertise in process optimization using AI and machine learning. He has experience developing value-added products from agricultural side streams and researching cultivated seafood production.
Dr. Lexi Duscher
Postdoctoral associate, Virginia Tech University, USA
Dr. Duscher’s research focuses on optimizing cost-effective and efficient fish cell culture for the development of cultivated seafood. She has experience structuring living fish cells into cultivated meat fillets via plant-based scaffolding and 3D bioprinting.
Defined Bioscience is awarded $1.5 million NIH SBIR grant
The National Institutes of Health (NIH) awarded Defined Bioscience a Phase II Small Business Innovation Research (SBIR) grant to advance human stem cell media. This research will provide complementary learnings for their GFI-funded cultivated seafood media research.
Learn about Dr. Kevan Main and Dr. Cathy Walsh’s work at Mote Marine Laboratory to develop cell lines and methodology for cultivated seafood.
Learn about Dr. Nataraja Yadavalli’s research to develop edible nanofiber scaffolds for Pacific white shrimp at CytoNest.
Explore research opportunities
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Although fish are one of the best dietary sources of long-chain omega-3 fatty acids (FAs), these compounds are mostly bioaccumulated from a fish’s diet rather than synthesized de novo. Consistent…
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Check out related resources
Analyzing cell culture medium costs
This white paper explains different routes to lowering the cost of cell culture medium and making cultivated meat economically viable.
Translating biomedical advances to cultivated meat (Biochemical Engineering Journal)
This peer-reviewed article discusses how advances from the biomedical cell culture industry can contribute to the development of cultivated meat.
Sustainable Seafood Initiative
Learn how plant-based, fermentation-derived, and cultivated seafood can improve the health and sustainability of oceans.