Designing cellular building blocks
2019 – 2021
Dr. Machluf is designing a cultivated meat platform based on scalable cellular building blocks and matching processing methodologies.
PRODUCTION PLATFORM: Cultivated
TECHNOLOGY SECTOR: Scaffolding
Project aims
This project aims to characterize two biomaterials for cellular building block applications. It will also develop oleogel microparticles for incorporation into cultivated meat to improve texture attributes. By combining cellular building blocks and oleogel microparticles, the research will produce thick-cut cultivated meat on fibrous scaffolds.
This work will create a scalable process for the creation of complex, thick-cut cultivated meat. It will also develop a platform for synthesis of cellular building blocks and oleogel microparticles to produce a wide variety of meat forms.
Principal researcher
Dr. Marcelle Machluf
Dean, Faculty of Biotechnology and Food Engineering, Technion – Israel Institute of Technology, Israel
Dr. Machluf has experience combining material engineering and life sciences to develop disease treatments and advanced regenerative medicine. She applies her expertise to gene therapy, drug delivery systems, cell bioencapsulation, and regenerative medicine. Her work leverages natural mechanisms to find safe technological approaches to combating diseases.
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Research grants
Learn about cutting-edge alternative protein research funded by GFI. Find funding opportunities for your own research.
Related research
Developing marbled cultivated beef
GFI is developing marbled cultivated beef with Dr. Amy Rowat at University of California, Los Angeles
3-D printing bioinks
Learn about GFI grantee Dr. Sara Oliveira’s work 3D bioprinting scaffolds for cultivated meat the International Iberian Nanotechnology Laboratory in Portugal.
Plant-based scaffolds
GFI is building plant-based tissue scaffolds for cultivated meat with Dr. Masatoshi Suzuki at University of Wisconsin, Madison
Explore research opportunities
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Cultivated
Scaffolding development for culinary and biomechanical requirements of cultivated seafood
A number of published studies have focused on scaffolds for cultivated meat (see Related Efforts) yet, to our knowledge, no studies have specifically attempted to formulate scaffolds for fish or…
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Fermentation
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Forging product development partnerships among ingredient suppliers and manufacturers
Opportunities exist to coordinate product development partnerships between ingredient suppliers, strategic partners, and product manufacturers to directly engage more holistically on product formulation.
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Computational models of perfusion flow through scaffolds
For tissue-structured cultivated meat production, the transition from the proliferation phase to differentiation phase may involve seeding cells onto a prefabricated scaffold within a perfusion bioreactor. Medium is then perfused…
