RealSense: Integrating biosensors for cultivated meat
Dr. Gadjanski and Dr. Radonic are integrating sensors and in-line monitoring systems into bioreactors for cultivated meat production.
PRODUCTION PLATFORM: Cultivated
TECHNOLOGY SECTOR: Bioprocess design
This project develops and integrates sensors and systems for in-line and real-time monitoring into bioreactors used for cultivated meat. This will improve efficiency and consistency of cultivated meat production.
Phase 1 of this project develops prototype sensors for in-situ measurements of biomass, nutrient, and metabolite quantities in growth media. To conduct in-line monitoring, it implements a “lab-on-a-chip” strategy that combines sensors with microfluidic devices. It uses a scale-down approach to solve process problems before scale translation. These sensors will reduce cost through medium recycling and enable maximization of cell proliferation per unit medium volume.
Phase 2 of this project identifies the most efficient configuration for integrating sensors into stirred-tank bioreactors. It optimizes the next generation of biomass, nutrient, and metabolite sensors and enables their configuration in bioreactors.
This work will improve bioprocess control in cultivated meat production through in-line monitoring systems. These systems could also enable media recycling, which would reduce the cost of cultivated meat production.
Dr. Ivana Gadjanski
Assistant Director for Science and Research, Associate Professor, BioSense Institute, University of Novi Sad, Serbia
Dr. Gadjanski possesses interdisciplinary expertise, with interests in bioengineering, synthetic biology, biosensors, and microfluidics. A Fulbright alumni from Columbia University, she promotes digital fabrication in STEAM fields in Southeast Europe as the founder of the nonprofit Fab Initiative.
Dr. Vasa Radonic
Senior Researcher, BioSense Institute, University of Novi Sad, Serbia
Dr. Radonic possesses expertise in sensors, microfluidics, modeling, and computational fluid dynamics. His work also draws on BioSense’s in-house nanotechnology, chemistry, and biology experts to address specific sensor requirements.
Explore the project website for more information about this team’s research.
View related grant projects
GFI grantee Dr. Mariana Petronela Hanga is researching culturing different cell types at the same time.
Learn about Dr. Marianne Ellis’s work at University of Bath to reduce the cost of bioreactors for cultivated meat production.
GFI grantee Dr. Simon Kahan at the Cultivated Meat Modeling Consortium is using computational modeling to improve bioreactor design for meat cultivation.
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Check out related resources
This lab-on-a-chip could lower the cost of cell-based meat
GFI research grant recipient Dr. Ivana Gadjanski is developing a new generation of sensors to monitor nutrients and biomass during cell-based meat production.
Poster presentation from the RealSense team
View the poster presentation that the RealSense team presented at the Good Food Conference.
Microfluidic sensor based on composite left-right handed transmission line
Read the RealSense team’s peer-reviewed paper, published in MDPI.