RealSense: Integrating biosensors for cultivated meat

2019-2022

Dr. Gadjanski and Dr. Radonic are integrating sensors and in-line monitoring systems into bioreactors for cultivated meat production.

PRODUCTION PLATFORM: Cultivated
TECHNOLOGY SECTOR:  Bioprocess design

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Project aims

This project develops and integrates sensors and systems for in-line and real-time monitoring into bioreactors used for cultivated meat. This will improve efficiency and consistency of cultivated meat production.

RealSense1

Phase 1 of this project develops prototype sensors for in-situ measurements of biomass, nutrient, and metabolite quantities in growth media. To conduct in-line monitoring, it implements a “lab-on-a-chip” strategy that combines sensors with microfluidic devices. It uses a scale-down approach to solve process problems before scale translation. These sensors will reduce cost through medium recycling and enable maximization of cell proliferation per unit medium volume.

RealSense2

Phase 2 of this project identifies the most efficient configuration for integrating sensors into stirred-tank bioreactors. It optimizes the next generation of biomass, nutrient, and metabolite sensors and enables their configuration in bioreactors.

This work will improve bioprocess control in cultivated meat production through in-line monitoring systems. These systems could also enable media recycling, which would reduce the cost of cultivated meat production.

Principal researchers

GFI grantee Dr. Ivana Gadjanski, Assistant Director for Science and Research, Associate Professor, BioSense Institute, University of Novi Sad, Serbia

2019-2021

Dr. Ivana Gadjanski

Assistant Director for Science and Research, Associate Professor, BioSense Institute, University of Novi Sad, Serbia

Dr. Gadjanski possesses interdisciplinary expertise, with interests in bioengineering, synthetic biology, biosensors, and microfluidics. A Fulbright alumni from Columbia University, she promotes digital fabrication in STEAM fields in Southeast Europe as the founder of the nonprofit Fab Initiative.


Dr. Vasa Radonic, Senior Researcher, BioSense Institute, University of Novi Sad, Serbia

2020-2022

Dr. Vasa Radonic

Senior Researcher, BioSense Institute, University of Novi Sad, Serbia

Dr. Radonic possesses expertise in sensors, microfluidics, modeling, and computational fluid dynamics. His work also draws on BioSense’s in-house nanotechnology, chemistry, and biology experts to address specific sensor requirements.

RealSense biosensor for cultivated meat production

RealSense

Explore the project website for more information about this team’s research.

Pattern of cells, representing cell culture for meat cultivation

Co-culturing cells

GFI grantee Dr. Mariana Petronela Hanga is researching culturing different cell types at the same time.

Steel fermentation tanks, representing bioreactors for cultivated meat production

Designing cost-effective bioreactors

Learn about Dr. Marianne Ellis’s work at University of Bath to reduce the cost of bioreactors for cultivated meat production.

Abstract representation of computational modeling for cultured meat

Computational modeling

GFI grantee Dr. Simon Kahan at the Cultivated Meat Modeling Consortium is using computational modeling to improve bioreactor design for meat cultivation.

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This lab-on-a-chip could lower the cost of cell-based meat

GFI research grant recipient Dr. Ivana Gadjanski is developing a new generation of sensors to monitor nutrients and biomass during cell-based meat production.

RealSense biosensor for cultivated meat production

Poster presentation from the RealSense team

View the poster presentation that the RealSense team presented at the Good Food Conference.

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Microfluidic sensor based on composite left-right handed transmission line 

Read the RealSense team’s peer-reviewed paper, published in MDPI. 

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