- Raw Materials, Ingredients, & Inputs
- Cell line development
Isolating cells is a primary initial R&D challenge for many cultivated meat companies. Procuring existing cell lines or establishing new lines also presents a barrier to entry for academic researchers wishing to contribute to advances in cultivated meat. Initial isolation protocols constitute fundamental knowledge best generated and disseminated in an open-access manner so that companies can focus on other aspects of the process with greater potential for competitive advantage. Once cell lines have been established, researchers cannot efficiently find them or negotiate access to them. At the same time, maintaining and shipping cell lines poses a burden to the labs that have developed them, even if those labs are amenable to sharing. Finding cell lines and protocols for seafood species is an even bigger challenge than for terrestrial species due to the nascency of aquatic cell culture and the number of species commonly consumed.
Coordinated efforts on several fronts can improve access to cell lines and isolation protocols. First, academic research aimed at improving isolation methods can lead to open-access protocols that will benefit the whole industry. The cell lines generated through these efforts should be shared broadly within academia and potentially also licensed to companies. A centralized repository—such as the Kerafast repository established in partnership with GFI—can manage license agreements, maintenance, and shipping. There is also a role for companies specializing in cell line development, acting as suppliers of cell lines for both research and commercial use. Finally, cultivated meat companies should consider licensing or sharing their lines as an additional revenue stream or to expand the pipeline of academic R&D that they can potentially in-license in the future. Some companies are already providing ready-to-use cell lines to their university collaborators. In cases where companies develop cell lines that they ultimately decide not to commercialize, it may make sense to share these lines more broadly to stimulate research that will ultimately benefit the industry as a whole while focusing efforts on their preferred species or cell type.
Easier access to cell lines and isolation protocols will produce a more favorable climate for cultivated meat innovation and encourage new researchers to join the field by lowering the barrier to entry. Cell lines made available with minimal restrictions on their use will see widespread adoption in the research community, leading to greater productivity in other areas that depend on cell line availability, such as media optimization, scaffolding, and bioreactor design. Use of consistent lines between different research groups will also help within reproducibility and comparing results between studies. With proper documentation of the isolation process, companies can even develop products with these same lines, establishing their value with proprietary innovations related to other aspects of the process or product. And all companies benefit from open-access protocols and established cell lines they can use as benchmarks for conducting their own cell line development work.
- Cell Farm aims to be a B2B cell line supplier.
- Through a partnership with Kerafast, GFI is spearheading an effort to streamline distribution of cell lines, with some flexibility in license terms.
- Several GFI grantees are developing relevant cell lines: Gareth Sullivan is developing cell lines from terrestrial meat species. Mote Marine Laboratory is developing cell lines from redfish and shrimp. Kyle Fish is developing cell lines from salmon.
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Improving our understanding of the relative advantages and disadvantages of different cell types for cultivated meat would enable companies to make these decisions more effectively with less duplicative effort.
Species-specific genomic studies enabling assay development for regulatory standards and cell line optimization
A suite of assays and genomic knowledge exists for humans and commonly used laboratory species such as mice or fruit flies. However, the same species-specific infrastructure does not exist equally…
Research to align on the appropriate assays would introduce standardization that can accelerate R&D efforts.
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