Fermentation icon Fermentation

Expanding options for food-safe genetic selection markers

Analysis of which food-safe selection markers exist and can be used orthogonally, as well as efforts to develop new selection markers, for alternative proteins.

Production platform
  • Fermentation icon Fermentation
Solution category
  • Research
  • Commercial
Value chain segment
  • R&D
Technology sector
  • Host strain development
Relevant actor
  • Industry
  • Academics
  • Startups

Description

Strain development efforts across plants, animal cells, and microbes often rely on selectable markers. Historically, many of these markers confer traits like antibiotic or herbicide resistance, which is not ideal. While some auxotrophic selection markers exist, these are often not orthogonal and thus not amenable to stacking for multi-trait selection. The alternative protein field would benefit from an analysis of which food-safe selection markers exist and can be used orthogonally, as well as efforts to develop new selection markers.

GFI resources

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