Fermentation icon Fermentation

Suppressing hyper-branching of filamentous fungi

Prolonging continuous cultivation of filamentous fungi by suppressing hyper-branching to improve texture and boost production efficiency.

Production platform
  • Fermentation icon Fermentation
Solution category
  • Research
  • Commercial
Value chain segment
  • R&D
  • Production
Technology sector
  • Bioprocess design
  • Host strain development
Relevant actor
  • Industry
  • Academics


The filamentous fungus Fusarium venenatum is grown in massive air-lift fermentors generating several tons per hour. However, these fermentors can only operate continuously for a few weeks before the appearance of hyper-branched variants in the population, which negatively impact the texture. If continuous cultivation could be prolonged by delaying the appearance of this phenotype, the production process could become much more efficient. Strain development approaches or process innovations, such as adjusting the cultivator conditions or introducing media supplements, may be able to address this challenge.

GFI resources

Sliced grilled fungi-based steak on a bed of greens and vegetables, by meati foods


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State of the Industry Report: Fermentation

This report details the commercial landscape, investments, regulatory developments, and scientific progress in the fermentation for alternative proteins industry.

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  • Cultivated icon Cultivated

Improving efficiency and assessment of adaptation to suspension growth

Improving methods for adapting cells to suspension culture can facilitate cell line development and bioprocess design for cultivated meat.

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  • Cultivated icon Cultivated
  • Fermentation icon Fermentation

Systematic investigation of growth factor needs and effects

Open-access research into growth factors required for proliferation, maintenance, and differentiation of cell types relevant to cultivated meat will support both academic and industry research efforts. This research could include…

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