Fermentation icon Fermentation

Suppressing hyper-branching of filamentous fungi

Prolonging continuous cultivation of filamentous fungi by suppressing hyper-branching to improve texture and boost production efficiency.

Production platform
  • Fermentation icon Fermentation
Solution category
  • Research
  • Commercial
Value chain segment
  • R&D
  • Production
Technology sector
  • Bioprocess design
  • Host strain development
Relevant actor
  • Industry
  • Academics

Description

The filamentous fungus Fusarium venenatum is grown in massive air-lift fermentors generating several tons per hour. However, these fermentors can only operate continuously for a few weeks before the appearance of hyper-branched variants in the population, which negatively impact the texture. If continuous cultivation could be prolonged by delaying the appearance of this phenotype, the production process could become much more efficient. Strain development approaches or process innovations, such as adjusting the cultivator conditions or introducing media supplements, may be able to address this challenge.

GFI resources

Sliced grilled fungi-based steak on a bed of greens and vegetables, by meati foods

Fermentation

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