Suppressing hyper-branching of filamentous fungi
Prolonging continuous cultivation of filamentous fungi by suppressing hyper-branching to improve texture and boost production efficiency.
- Bioprocess design
- Host strain development
The filamentous fungus Fusarium venenatum is grown in massive air-lift fermentors generating several tons per hour. However, these fermentors can only operate continuously for a few weeks before the appearance of hyper-branched variants in the population, which negatively impact the texture. If continuous cultivation could be prolonged by delaying the appearance of this phenotype, the production process could become much more efficient. Strain development approaches or process innovations, such as adjusting the cultivator conditions or introducing media supplements, may be able to address this challenge.
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State of the Industry Report: Fermentation
This analysis of fermentation for alternative protein production covers science, entrepreneurship, policy, and industry investments.
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Improving efficiency and assessment of adaptation to suspension growth
Improving methods for adapting cells to suspension culture can facilitate cell line development and bioprocess design for cultivated meat.
Systematic investigation of growth factor needs and effects
Open-access research into growth factors required for proliferation, maintenance, and differentiation of cell types relevant to cultivated meat will support both academic and industry research efforts. This research could include…
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