The Science of Alt Protein: Glycoengineering fungal cell factories — Implications for recombinant protein production
Event description
Filamentous fungi are widely used for recombinant protein production due to their high secretion capacity and GRAS status. However, fungal N-glycosylation pathways produce high-mannose structures that differ from mammalian complex glycans, potentially affecting protein function, stability, and immunogenicity.
This presentation from André Damasio, Ph.D., will discuss glycoengineering strategies for fungal cell factories producing recombinant proteins. Using Aspergillus nidulans as a model system, Dr. Damasio explores approaches ranging from glycoproteome mapping and site-specific engineering to pathway-level rewiring via CRISPR-Cas9.
The work addresses the fundamental challenge that fungal high-mannose glycans differ from mammalian complex structures, potentially affecting protein function. Join us to learn how using advanced gene-editing tools to reprogram fungi opens new possibilities for recombinant protein production.
Meet the speaker
Dr. André Damasio
ASSOCIATE PROFESSOR
INSTITUTE OF BIOLOGY – UNIVERSITY OF CAMPINAS (UNICAMP), BRAZIL
Dr. André Damasio is an Associate Professor in the Department of Biochemistry and Tissue Biology at the Institute of Biology, University of Campinas (UNICAMP), Brazil. He received his Ph.D. in Biochemistry from the University of São Paulo in 2011, with research periods at Oklahoma State University and the Institute of Catalysis and Petroleochemistry in Madrid. He joined UNICAMP in 2015 as an Assistant Professor after completing postdoctoral training at the Brazilian Biorenewables National Laboratory. His research group is dedicated to studying microbial biomanufacturing, mainly the production of recombinant proteins and enzymes using filamentous fungi as cell factories.
Upcoming events
View all events
How alternative protein companies can work with the U.S. National Laboratories
Join us to learn ways alternative protein companies can work with the U.S. National Laboratories.
High-Impact Giving Strategies for Reducing Biodiversity Loss
GFI joins Giving Green to discuss how strategic philanthropy can help address biodiversity loss.
Future Food-Tech San Francisco – Breaking Barriers to Scale: Cost, Efficiency, and De-Risking Bioprocessing
From modular systems to shared infrastructure, the future of bioprocessing is getting real. Join GFI’s Amanda Hildebrand at Future Food-Tech San Francisco as she moderates a dynamic breakout session on…
Bruce Friedrich at Politics & Prose
Meat: How the Next Agricultural Revolution Will Transform Humanity’s Favorite Food—and Our Future – with Nicolás Rivero.
Bruce Friedrich at Johns Hopkins University: Meat — a homecoming conversation
Event description Co-hosted with the Center for a Livable Future (based at the Johns Hopkins Bloomberg School of Public Health), this event is a chance to connect the dots between…
Alternative Protein Symposium: Bridging Science and Society
Join Bruce Friedrich and our Alt Protein Project leaders from NC State, Duke University, and Virginia Tech at the Alternative Protein Symposium: Bridging Science and Society.
Animal-Free Meat: The Next Agricultural Revolution
Come learn how science, policy, and industry can work together to satisfy the world’s soaring demand for meat, no animals required.
